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KMID : 1197720210140030221
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대한파킨슨병 및 이상운동질환 학회지
2021 Volume.14 No. 3 p.221 ~ p.225
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Investigation of Nocturnal Hypokinesia and Health-Related Quality of Life in Parkinsonian Patients with the Korean Version of the Nocturnal Hypokinesia Questionnaire
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Choi Ji-Hyun
Lee Jee-Young
Shin Chae-Won
Yoo Dal-Lah
Yoo Dal-Lah
Im Jin-Hee
Woo Kyung-Ah
Kim Han-Joon
Ahn Tae-Beom
Kim Jong-Min
Jeon Beom-Seok
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Abstract
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Objective: To assess nocturnal hypokinesia using the Korean version of the Nocturnal Hypokinesia Questionnaire (NHQ-K) in Parkinson’s disease (PD) patients across disease stages.
Methods: We developed the NHQ-K and performed questionnaire-based interviews with 108 PD patients from three referral hospitals. Clinical associations of nocturnal hypokinesia and its impact on health-related quality of life (HRQoL) were also analyzed.
Results: The NHQ-K showed acceptable internal consistency (0.83) and interrater reliability (0.95). Nocturnal hypokinesia significantly affected HRQoL in PD patients at both the early and advanced stages (adjusted p < 0.001). Increased severity of nocturnal hypokinesia was associated with dyskinesias, off-period disability, apathy, and anxious mood in PD patients (adjusted p < 0.01) after controlling for disease severity and medication dose.
Conclusion: The NHQ-K is useful for screening nocturnal hypokinesia in PD patients. Given the high impact of nocturnal hypokinesia on HRQoL, comprehensive management of nocturnal disability is needed for PD patients.
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KEYWORD
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Parkinson’s disease, Nocturnal Hypokinesia Questionnaire, Quality of life, Validation study
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